Trailhead Biosystems is a Beachwood, Ohio biotechnology company that manufactures human cells derived from induced pluripotent stem cells (iPSCs) for drug discovery, toxicity testing, and regenerative medicine research. Founded in 2015 as a spinout from the Cleveland Clinic and Case Western Reserve University, it uses a proprietary High-Dimensional Design-of-Experiments (HD-DoE) platform combined with high-throughput robotics to optimize differentiation protocols across many variables at once. The company sells off-the-shelf TrailBio cell products alongside small molecules, custom differentiation services, and therapeutic partnerships. It maintains R&D and manufacturing in Beachwood with a satellite office in Cambridge, Massachusetts.