Modulate Bio Inc. is a preclinical neuroscience drug discovery company based at the Pagliuca Harvard Life Lab in Allston, Massachusetts. It develops small-molecule GABAA positive allosteric modulators designed to restore healthy brain receptor function without overactivating it. Its lead program targets Essential Tremor, with epilepsy in close pursuit and anxiety and rare neurological diseases as later indications. The company has reported in vivo proof-of-concept in mice and says it is close to naming a development candidate for Essential Tremor.