Briquilimab
Monoclonal antibody therapeuticAn investigational aglycosylated monoclonal antibody targeting KIT (CD117) that blocks stem cell factor signaling and depletes mast cells and hematopoietic stem cells via apoptosis, in development for chronic urticaria and progressing toward a pre-BLA meeting in severe combined immunodeficiency (SCID).
- Targets KIT (CD117) and blocks stem cell factor binding
- Aglycosylated antibody format
- Depletes mast cells through apoptosis
- Subcutaneous dosing evaluated in the BEACON Phase 1b/2a study in chronic spontaneous urticaria