In vivo cell engineering platform
Cell and gene therapy platformA platform of programmable DNA medicines that reprogram immune and other cell types directly within the body, led by a pre-clinical in vivo cell therapy program for autoimmune diseases funded by the ARPA-H EMBODY program.
- Cell type-specific synthetic promoters for precise expression
- Delivery-agnostic expression cassettes usable across viral and non-viral vehicles
- DNA-loaded polymeric nanoparticle delivery
- Lead autoimmune-disease program funded through first-in-human trial by ARPA-H