KO-7246
Small-molecule drug candidate (preclinical)Next-generation, highly selective small-molecule menin inhibitor optimized for chronic metabolic disease; in preclinical models it selectively expanded pancreatic beta cells, increased insulin production and improved glycemic control in Type 1 and Type 2 diabetes models.
- Highly selective menin inhibition
- Preclinical beta-cell expansion and increased insulin production
- Durable glycemic improvements persisting after treatment stopped in preclinical models
- Phase 1 trial expected to begin by end of 2027, with data in 2028