Anti-sIL7R monoclonal antibody program
Preclinical biologic therapeuticA preclinical, first-in-class series of monoclonal antibodies highly specific for soluble IL7 receptor (sIL7R), designed to normalize elevated sIL7R levels while leaving membrane-bound IL7R signaling intact.
- Selective for soluble IL7R, sparing membrane-bound IL7R
- Targets a prevalent IL7R SNP associated with 2-3x higher circulating sIL7R
- Aims to reduce autoreactive T-cell expansion and restore immune homeostasis
- Indications under investigation include progressive multiple sclerosis, lupus nephritis, rheumatoid arthritis and type 1 diabetes