PASylated long-acting peptide program for chronic heart failure
Preclinical therapeutic programA preclinical therapeutic program applying XL-protein's PASylation technology to a cardiovascular peptide, extending its plasma half-life so it can be developed as a chronic treatment for heart failure.
- Peptide therapeutic targeting chronic heart failure
- PASylation half-life extension using proline/alanine/serine polypeptide fusion
- Reported 10-100x reduction in renal clearance versus the unmodified peptide
- Biological, non-immunogenic alternative to PEGylation